Management of Gastrointestinal Stromal Tumors: Experience of a University Hospital
Published: 2020-09-26
Page: 148-153
Issue: 2020 - Volume 3 [Issue 1]
Driss Erguibi
Faculty of Medicine and Pharmacy of Casablanca, Service of Digestive Cancer Surgery and Liver Transplantation III, Hassan II University, CHU Ibn Rochd, Casablanca, Morocco.
Ettaoussi Abdelhak
Faculty of Medicine and Pharmacy of Casablanca, Service of Digestive Cancer Surgery and Liver Transplantation III, Hassan II University, CHU Ibn Rochd, Casablanca, Morocco.
Asmar Mohamed *
Faculty of Medicine and Pharmacy of Casablanca, Service of Digestive Cancer Surgery and Liver Transplantation III, Hassan II University, CHU Ibn Rochd, Casablanca, Morocco.
Saâd Rifki Jai
Faculty of Medicine and Pharmacy of Casablanca, Service of Digestive Cancer Surgery and Liver Transplantation III, Hassan II University, CHU Ibn Rochd, Casablanca, Morocco.
Rachid Boufettal
Faculty of Medicine and Pharmacy of Casablanca, Service of Digestive Cancer Surgery and Liver Transplantation III, Hassan II University, CHU Ibn Rochd, Casablanca, Morocco.
Farid Chehab
Faculty of Medicine and Pharmacy of Casablanca, Service of Digestive Cancer Surgery and Liver Transplantation III, Hassan II University, CHU Ibn Rochd, Casablanca, Morocco.
*Author to whom correspondence should be addressed.
Abstract
Gastrointestinal stromal tumors or GISTs are rare tumors: 1 to 3% of malignant tumors gastrointestinal. 65% of these tumors sit in the stomach, 25% in the small bowel, 5-10% in the colon-rectum...
They occur secondary to activating mutations of the KIT or PDGFRA receptors. In 85% of cases, and are diagnosed at a localized stage in about 85% of cases. The spontaneous recurrence rate for patients who have undergone surgery and have a complete resection is approximately 40% at 10 years.
In this article we present a case of a gregarious stromal tumor whose age of occurrence was early and recurrence after complete surgical resection and targeted therapy was rapid and aggressive.
Also we discuss in the light of the literature, the results, surgical treatment, targeted therapy, histological findings and prognostic factors on which the risk of recurrence depends.
Keywords: Gastrointestinal stromal tumors (GIST), pathogenic factors, prognosis, early recurrence.