Asian Journal of Research and Reports in Gastroenterology

A Rare Cause of Dysphagia: Esophageal Papillomatosis Complicated by Squamous Cell Carcinoma

H. Mahtal *

Hepato-Gastro-Enterology Department, UHC Ibn Rochd, Casablanca, Morocco.

S. Nacer

Hepato-Gastro-Enterology Department, UHC Ibn Rochd, Casablanca, Morocco.

S. Abadi

Hepato-Gastro-Enterology Department, UHC Ibn Rochd, Casablanca, Morocco.

Fz. Elghaoussi

Hepato-Gastro-Enterology Department, UHC Ibn Rochd, Casablanca, Morocco.

M. Tahiri

Hepato-Gastro-Enterology Department, UHC Ibn Rochd, Casablanca, Morocco.

F. Haddad

Hepato-Gastro-Enterology Department, UHC Ibn Rochd, Casablanca, Morocco.

W. Hliwa

Hepato-Gastro-Enterology Department, UHC Ibn Rochd, Casablanca, Morocco.

A. Bellabah

Hepato-Gastro-Enterology Department, UHC Ibn Rochd, Casablanca, Morocco.

W. Badre

Hepato-Gastro-Enterology Department, UHC Ibn Rochd, Casablanca, Morocco.

E. M. Choukri

Digestive Emergency Department, UHC Ibn Rochd, Casablanca, Morocco.

K. El Hattabi

Digestive Emergency Department, UHC Ibn Rochd, Casablanca, Morocco.

Fz. Bensardi

Digestive Emergency Department, UHC Ibn Rochd, Casablanca, Morocco.

A. El Bakouri

Digestive Emergency Department, UHC Ibn Rochd, Casablanca, Morocco.

M. Bouali

Digestive Emergency Department, UHC Ibn Rochd, Casablanca, Morocco.

A. Fadil

Digestive Emergency Department, UHC Ibn Rochd, Casablanca, Morocco.

*Author to whom correspondence should be addressed.

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Abstract

Esophageal papillomatosis is a fairly rare illness that is thought to have a benign clinical course. Recent findings highlight the possibility of a malignancy emerging in connection with esophageal squamous papillomatosis. A case of esophageal papillomatosis is documented, which was worsened by the development of esophageal invasive squamous cell carcinoma following numerous nondiagnostic endoscopic biopsies. In addition, the patient developed squamous cell carcinoma in the oral cavity. Extensive esophageal papillomatosis and recurrent dysphagia symptoms should prompt an examination into an underlying malignancy.

Keywords: HPV, squamous papilloma of the esophagus, squamous cell carcinoma of the esophagus, gastroscopy

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References

Adler RH, Carberry DM, Ross CA. Papilloma of the esophagus. Association with hiatus hernia. J Thorac Surg. 1959;37:625-35.

Mosca S, Manes G, Monaco R et al. Squamous papilloma of the esophagus: long-term follow up. J Gastroenterol Hepatol. 2001;16:857 – 861.

Sablich R, Benedetti G, Bignucolo S et al. Squamous cell papilloma of the esophagus: report of 35 endoscopic cases. Endoscopy. 1988;20:5–7.

Talamini G, Capelli P, Zamboni G et al. Alcohol, smoking and papillomavirus infection as risk factors for esophageal squamous-cell papilloma and esophageal squamous-cell carcinoma in Italy. Int J Cancer. 2000;86(6):874-8.

Takeshita K, Murata S, Mitsufuji S et al. Clinicopathological characteristics of esophageal squamous papillomas in Japanese patients with comparison of findings from Western countries. Acta Histochem Cytochem. 2006;39(1):23-30.

Fernández-Rodríguez CM, Badia-Figuerola N, Ruiz del Arbol L et al. Squamous papilloma of the esophagus: Report of six cases with long-term follow-up in four patients. Am J Gastroenterol. 1986; 81(11):1059-62.

Odze R, Antonioli D, Shocket D et al. Esophageal squamous papillomas. A clinicopathologic study of 38 lesions and analysis for human papillomavirus by the polymerase chain reaction. Am J Surg Pathol. 1993;17:803–812.

Narayani RI, Young GS. Recurrent proximal esophageal stricture associated with dysplasia in squamous cell papillomatosis. Gastrointest Endosc. 2002;56(4):591-4.

Park SH, Bang BW, Kim HG et al. A case of esophageal squamous papillomatosis. Korean J Intern Med. 2012;27(2):243.

Inomata S, Aoyagi K, Eguchi K et al. Giant esophageal papilloma. Gastrointest Endosc. 2004; 60(3):430.

Collège Français des Pathologistes CoPath.

Bohn OL, Navarro L, Saldivar J et al. Identification of human papillomavirus in esophageal squamous papillomas. World J Gastroenterol. 2008;14(46):7107-11.

Chang F, Janatuinen E, Pikkarainen P et al. Esophageal squamous cell papillomas: Failure to detect human papillomavirus DNA by in situ hybridization and polymerase chain reaction. Scand J Gastroenterol. 1991;26:535–43.

Van Cutsem E, Geboes K, Visser L. Squamous papillomatosis of the oesophagus with malignant degeneration and demonstration of the human papilloma virus. Eur J Gastroenterol Hepatol. 1992;3:561–6.

Waluga M, Hartleb M, Sliwinski ZK et al. Esophageal squamous-cell papillomatosis complicated by carcinoma. Am J Gastroenterol. 2000;95:1592–3.

Orlowska J, Jarosz D, Gugulski A, Pachlewski J, Butruk E. Squamous cell papillomas of the esophagus: Report of 20 cases and literature review. Am J Gastroenterol. 1994;89:434–7.

Poljak M, Orlowska J, Cerar A. Human papillomavirus infection in esophageal squamous cell papillomas: a study of 29 lesions. Anticancer Res. 1995;15(3):965-9.

Inomata S, Aoyagi K, Eguchi K, Sakisaka S. Giant esophageal papilloma Gastrointest Endosc. 2004;60(3):430.

Narayani RI, Young GS. Recurrent proximal esophageal stricture associated with dysplasia in squamous cell papillomatosis. Gastrointest Endosc. 2002; 56(4):591-4.

Park SH, Bang BW, Kim HG, Shin YW, Kim L. A case of esophageal squamous papillomatosis. Korean J Intern Med. 2012;27(2):243.

Bouvard V, Baan R, Straif K et al. WHO International Agency for Research on Cancer Monograph Working Group. A review of human carcinogens--Part B: biological agents. Lancet Oncol. 2009;10(4):321-2.

Spinelli P. Papilloma esofagei: Esperienza personale e revisione casistica. Gior Ital End Dig 1989;12:209-12.