An Assessment of Diabetes Amelioration Potentiality of Whole Extract of Heliotropium indicum in a Diet Mixed Dose-dependent Approach
Published: 2022-12-31
Page: 136-144
Issue: 2022 - Volume 5 [Issue 1]
Abdur Rahaman Sabbir
Department of Pharmacy, University of Asia Pacific, Farmgate, Dhaka, Bangladesh.
Raisa Sharmili Habib
Department of Pharmacy, Faculty of Pharmacy, University of Dhaka, Dhaka 1000, Bangladesh.
Najibah Nasrin
Department of Pharmacy, Faculty of Pharmacy, University of Dhaka, Dhaka 1000, Bangladesh.
Amatun Noor Prapty
Department of Pharmacy, University of Asia Pacific, Farmgate, Dhaka, Bangladesh.
Mashia Subha Lami
Department of Pharmacy, Faculty of Pharmacy, University of Dhaka, Dhaka 1000, Bangladesh.
Md. Rafat Tahsin *
Department of Pharmaceutical Sciences, North South University, Plot # 15, Block # B, Bashundhara R/A, Dhaka 1229, Bangladesh.
Ishrat Jahan
Department of Pharmacy, University of Asia Pacific, Farmgate, Dhaka, Bangladesh.
Fahima Aktar
Molecular Pharmacology and Herbal Drug Research Laboratory, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka 1000, Bangladesh.
Tahmina Aktar
Department of Physiology, Dhaka Medical College, Dhaka, Bangladesh.
Jakir Ahmed Chowdhury
Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Dhaka, Dhaka 1000, Bangladesh.
K. M. Khairul Alam
Department of Pharmacy, Jahangirnagar University, Savar, Dhaka-1342, Bangladesh.
Shaila Kabir
Molecular Pharmacology and Herbal Drug Research Laboratory, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka 1000, Bangladesh.
Abu Asad Chowdhury
Molecular Pharmacology and Herbal Drug Research Laboratory, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka 1000, Bangladesh.
Md. Shah Amran
Molecular Pharmacology and Herbal Drug Research Laboratory, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka 1000, Bangladesh.
*Author to whom correspondence should be addressed.
Abstract
Context: So many plants are reputed to possess diabetes ameliorating potentiality from ancient times. Some of those are proven as anti-diabetic. In contrast, the therapeutic potentiality of others is evidenced as either baseless or has not been proven yet under the light of in vivo analysis. Heliotropium indicum, grows roadside and wildly is also considered as anti-diabetic species in complementary and alternative treatment practice.
Objective: The aim of this study was to ascertain the therapeutic effects of Heliotropium indicum whole extract and figure out its safety profile to ameliorate diabetic conditions using the plant material.
Materials and Methods: Dried powder of Heliotropium indicum was dipped in ethanol. Next, extract was gathered after rotary evaporation. Alloxan monohydrate induced diabetic rats were treated with extract in a diet mixed manner.
Results and Discussion: Blood glucose levels were measured in both diabetic and non-diabetic rats over the course of the study. Upon measurement of blood glucose levels, all doses of Heliotropium indicum were found to decrease the elevated blood glucose levels in rats. However, only 750 mg/kg (p<0.05) reduces blood sugar levels. Thus, the average dose delivered the highest efficiency due to higher food and dose consumption.
Conclusion: The study concluded that metformin and leaf extract improved the diabetes-induced medical condition. It essentially shows that Heliotropium indicum extract could be used as a significant therapy for treating diabetes.
Keywords: Heliotropium indicum, blood sugar, extract, alloxan, In-vivo
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